- Sandwich Shop Restaurants, West Helena
- Schools For The Physically Challenged, West Helena
- Scrap & Waste Materials, West Helena
- Screen Printing, West Helena
- Seafood Restaurants, West Helena
- Secondary Schools, West Helena
- Security & Commodity Brokers, West Helena
- Sewer Construction Contractors, West Helena - Sewer Line, Pipe Installation & Repair Services
- Shopping & Shopping Services, West Helena
- Siding Contractors, West Helena - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
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- Signs, West Helena
- Social Services & Welfare, West Helena
- Special Education & Care, West Helena
- Specialty Stores, West Helena
- Sporting Goods Manufacturers, West Helena
- Sporting Goods Stores, West Helena
- State Government, West Helena
- Swimming Pools & Equipment Manufacturers, West Helena
- Swimming Pools Supplies, Equipment & Accessories, West Helena
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